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Email: xrdong@fudan.edu.cn

Ph.D in bioinformatics, Associate Researcher

Children's Hospital of Fudan University, Shanghai, China

ResearchGate main page (https://www.researchgate.net/profile/Xinran-Dong-2)

Biography

Since 2017 working in the Children’s Hospital of Fudan University, Dr. Xinran Dong has been engaged in the algorithm development involved in genetic testing pipeline and disease mechanism study, data analysis for clinical cohort and AI (artificial intelligence) pipeline construction. The developed algorithms have not only solved scientific and clinical problems, but also been deployed and applied in routine work through the construction of web service platforms. She joined the primary care force of IRDIRC (International Rare Diseases Research Consortium). As a patient of rare disease, Xinran Dong has decided to devote her life to the field of rare disease study.

Education

Research Interests

Selected publications

  1. Dong Xinran#, Ding Liang, Thrasher Andrew, Wang Xinge, Liu Jingjing, Pan Qingfei, Rash Jordan, Dhungana Yogesh, Yang Xu, Risch Isabel, Li Yuxin, Yan Lei, Rusch Michael, McLeod Clay, Yan Koon-Kiu, Peng Junmin, Chi Hongbo, Zhang Jinghui, Yu Jiyang. NetBID2 provides comprehensive hidden driver analysis [J]. Nature Communications, 2023, 14(1): 2581.
  2. Peng Xiaomin#, Dong Xinran#, Wang Yaqiong, Wu Bingbing, Wang Huijun, Lu Wei, Xiao Feifan, Yang Lin, Li Gang, Zhou Wenhao, Liu Bo, Lu Yulan. Overcoming the Pitfalls of Next-Generation Sequencing–Based Molecular Diagnosis of Shwachman-Diamond Syndrome [J]. The Journal of Molecular Diagnostics, 2022,
  3. Chen Huiyao#, Chen Xiang#, Hu Liyuan, Ye Chang, Zhang Jiantao, Cheng Guoqiang, Yang Lin, Lu Yulan, Dong Xinran, Zhou Wenhao. Rare-variant collapsing analyses identified risk genes for neonatal acute respiratory distress syndrome [J]. Computational and Structural Biotechnology Journal, 2022, 20(5047-5053.
  4. Tang Meiling#, Chen Xiang#, Ni Qi, Lu Yulan, Wu Bingbing, Wang Huijun, Yin Zhaoqing, Zhou Wenhao*, Dong Xinran*. Estimation of hereditary fructose intolerance prevalence in the Chinese population [J]. Orphanet Journal of Rare Diseases, 2022, 17(1)
  5. Dong Xinran#, Xiao Tiantian, Chen Bin, Lu Yulan, Zhou Wenhao. Precision medicine via the integration of phenotype-genotype information in neonatal genome project [J]. Fundamental Research, 2022
  6. 陈宾#,董欣然#,王慧君,吴冰冰,杨琳,王潇,王雅琼,倪琦,李川,周文浩,卢宇蓝；复旦大学附属儿科医院高通量测序数据一体化全流程闭环分析系统及临床应用案例分析; 中国循证儿科杂志, 2022, 17(3): 202.
  7. Pang Zhi#, Dong Xinran#, Deng Huayun#, Wang Chengzhi, Liao Xiaodong, Liao Chunhua, Liao Yahui, Tian Weidong, Cheng Jinke, Chen Guoqiang, Yi Haiying, Huang Lei*. MUC1 triggers lineage plasticity of Her2 positive mammary tumors [J]. Oncogene, 2022, 41(22): 3064-3078.
  8. Ni Qi#; Chen Xiang#, Zhang Ping, Yang Lin, Lu Yulan, Xiao Feifan, Wu Bingbing, Wang Huijun, Zhou Wenhao, Dong Xinran. Systematic estimation of cystic fibrosis prevalence in Chinese and genetic spectrum comparison to Caucasians. Orphanet Journal of Rare Diseases. 17, 129 (2022). https://doi.org/10.1186/s13023-022-02279-9
  9. Xiao Tiantian#, Ni Qi, Chen Huiyao, Wang Huijun, Yang Lin, Wu Bingbing, Cao Yun, Cheng Guoqiang, Wang Laishuan, Hu Liyuan, Mei Hongfang, Lu Yulan, Gong Mengchun, Dong Xinran*, Zhou Wenhao. High-risk phenotypes of genetic disease in a Neonatal Intensive Care Unit population [J]. Chinese Medical Journal, 2022, Publish Ahead of Print
  10. Dong Xinran#, Kong Yanting, Xu Yan, Zhou Yuanfeng, Wang Xinhua, Xiao Tiantian, Chen Bin, Lu Yulan, Cheng Guoqiang, Zhou Wenhao; Development and validation of Auto-Neo-EEG to estimate brain age and predict report conclusion for Electroencephalography monitoring data in neonatal intensive care units; Annals of Translational Medicine; SCI; (2021) 21-1564.
  11. Dong, Xinran#; Yang, Lin#; Liu, Kaiyi; Ji, Xiaoli; Tang, Chuanqing; Li, Wanxing; Ma, Ling; Mei, Yuting; Peng, Ting; Feng, Ban; Wu, Ziyan; Tang, Qingyuan; Gao, Yanyan; Yan, Kai; Zhou, Wenhao; Xiong, Man; Transcriptional networks identify Synaptotagmin-like 3 as a hidden regulator of cortical neuron migration during early neurodevelopment, Cell Reports, 2021, 34(9):108802.
  12. Luo,Zaili#; Dong,Xinran#; Yu,Jianzhong#; Xia,Yong#; Berry,Kalen P.; Rao,Rohit; Xu,Lingli; Xue,Ping; Chen,Tong; Lin,Yifeng; Yu,Jiyang; Huang,Guoying; Li,Hao; Zhou,Wenhao; Lu,Q. Richard*; Genomic and Transcriptomic Analyses Reveals ZNF124 as a Critical Regulator in Highly Aggressive Medulloblastomas, Frontiers in Cell and Developmental Biology, 2021, 9:634056.
  13. Dong, Xinran#; Liu, Bo#; Yang, Lin; Wang, Huijun; Wu, Bingbing; Liu, Renchao; Chen, Hongbo; Chen, Xiang; Yu, Sha; Chen, Bin; Wang, Sujuan; Xu, Xiu; Zhou, Wenhao; Lu, Yulan*; Clinical exome sequencing as the first-tier test for diagnosing developmental disorders covering both CNV and SNV: a Chinese cohort, Journal of Medical Genetics, 2020, 57(8): 558-566.
  14. Wu Jingfang#, Dong Xinran#, Li Wen#, Zhao Liping, Zhou Li, Sun Shan, Li Huawei. Dibenzazepine promotes cochlear supporting cell proliferation and hair cell regeneration in neonatal mice [J]. Cell Proliferation, 2020, 53(9): .(期刊论文)
  15. 秦谦#, 陈乡#, 卢宇蓝, 吴冰冰, 王慧君, 董欣然, 杨琳, 周文浩. ALDOB基因复合杂合变异致遗传性果糖不耐受饮食控制30年1例报告并文献复习 [J]. 中国循证儿科杂志, 2018, 13(04): 34-39.
  16. 秦谦#; 刘博#; 杨琳; 吴冰冰; 王慧君; 董欣然; 卢宇蓝; 周文浩; 基于高通量测序技术的拷贝数变异筛选分析流程的建立及应用, 中国循证儿科杂志, 2018, 13(4): 275-279.